Why You Hate Uncertainty & The New Science of Living Longer

May 11, 2026 · 49m

Have you ever struggled with a problem—only to have the answer suddenly appear when you stopped trying? It feels almost like magic, but it’s actually your brain working in a very specific way when you step back. https://drexel.edu/now/archive/2016/March/Insight_Correctness/ We all want to know what’s going to happen next. But life doesn’t work that way. In fact, the real challenge may not be uncertainty itself—but our growing discomfort with it. Simone Stolzoff, journalist and author of How to Not Know: The Value of Uncertainty in a World that Demands Answers (https://amzn.to/428rpWb), explains why we crave certainty, why that craving can make life harder, and how learning to tolerate—and even embrace—uncertainty can change the way you experience the world. You’ve probably heard that your health is shaped by both your genes and your lifestyle. But how much control do you really have? Are some outcomes unavoidable—or can your daily choices actually override genetic risk? Dr. Florence Comite, endocrinologist and expert in longevity and precision medicine, has spent decades studying how to optimize health at the individual level. In our conversation, she explains how genes influence y…

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